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KMID : 1037820140030020083
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Journal of Pain and Autonomic Disorders
2014 Volume.3 No. 2 p.83 ~ p.87
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Occurrence of Taxane Induced Acute Pain Syndrome In Patient with Breast Cancer: A Preliminary Study
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Lee Hyung-Soo
Kim Gun-Min
Sohn Joo-Hyuk
Kim Seung-Min
Shin Ha-Young
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Abstract
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Background: Taxane-induced acute pain syndrome (T-APS) had been recognized as well as taxane induced peripheral neuropathy, but its characteristics and natural history have not been well delineated. We observed the occurrence of T-APS and neurologic deficit in patients with breast cancer who received taxane for neoadjuvant or adjuvant setting.
Methods: Patients with breast cancer who were scheduled to receive paclitaxel or docetaxel were included. We performed history taking and neurologic examination at baseline and every 3 weeks after each cycle until three cycles of treatment.
Results: During three cycles, positive and negative sensory symptoms were developed in ten and six patients, respectively. General myalgia and arthralgia was developed in eight and three patients, respectively. After the first cycle of treatment, pain was developed in six patients. Although pain was not developed in four patients after the first cycle, temperature and vibration sensory deficits were detected in all of them.
Conclusions: These findings suggest that T-APS is associated with the neuronal damages from the early stage of taxane therapy and that taxane affects small unmyelinated fiber as well as large fiber from early stage.
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KEYWORD
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Taxoids, Acute pain, Neuralgia, Polyneuropathies, Drug-related side effects side effets and adverse reactions
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